SCHEMBL8914562

SCHEMBL8914562

c1ccc([Si]2(c3ccccc3)CCC2)cc1

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.32
HPGD P15428 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
MGLL Q99685 1/20 0.32
HSD17B10 Q99714 1/20 0.32
TSHR P16473 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3798583 0.94 MAPT (0.32) MAPTHPGDSMN1; SMN2MGLLHSD17B10
SCHEMBL20087445 0.92 MAPT (0.30) MAPTHPGDSMN1; SMN2MGLLHSD17B10
SCHEMBL3898942 0.92 MAPT (0.30) MAPTHPGDSMN1; SMN2MGLLHSD17B10
SCHEMBL5496477 0.92 MAPT (0.30) MAPTHPGDSMN1; SMN2MGLLHSD17B10
SCHEMBL15637376 0.88 MAPT (0.35) MAPTHPGDSMN1; SMN2MGLLHSD17B10
SCHEMBL18131846 0.78
SCHEMBL8977300 0.78
SCHEMBL19273268 0.76 HTR2C (0.39) TSHR
SCHEMBL7715185 0.75 MAPT (0.35) MAPTHPGDSMN1; SMN2MGLLHSD17B10
SCHEMBL8015888 0.74 NPC1 (0.33) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120193288-A Method for synthesizing silanol by electrochemical-mediated ring opening of cyclobutane silane 南京林业大学 2025-06-24 CN claimed
JP-7330909-A None JP disclosed
CN-120193288-A Method for synthesizing silanol by electrochemical-mediated ring opening of cyclobutane silane 南京林业大学 2025-06-24 CN disclosed
CN-120004934-A Preparation method of benzo-silicon-containing octatomic ring compound 郑州大学 2025-05-16 CN disclosed
US-10370588-B2 Organometallic compound and organic light-emitting device including the same SAMSUNG ELECTRONICS CO., LTD. (KR) 2019-08-06 US disclosed
US-9487629-B2 Method for preparing a statistical copolymer based on diene monomers and cyclic carbosilane monomers COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2016-11-08 US disclosed
US-20160190484-A1 ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO., LTD. (KR) 2016-06-30 US disclosed
US-20150274896-A1 METHOD FOR PREPARING A STATISTICAL COPOLYMER BASED ON DIENE MONOMERS AND CYCLIC CARBOSILANE MONOMERS MICHELIN RECHERCHE ET TECHNIQUE, S.A. (CH) 2015-10-01 US disclosed
EP-2904034-A1 METHOD FOR PREPARING A STATISTICAL COPOLYMER BASED ON DIENE MONOMERS AND CYCLIC CARBOSILANE MONOMERS Compagnie Générale des Etablissements Michelin (FR) 2015-08-12 EP disclosed
WO-2014053509-A1 METHOD FOR PREPARING A STATISTICAL COPOLYMER BASED ON DIENE MONOMERS AND CYCLIC CARBOSILANE MONOMERS COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2014-04-10 WO disclosed
US-5663397-A MULTISTAGE PROCESS FORMING OXYSILICON RING ENLARGEMENT BY REACTION WITH ACID HALIDE IN THE PRESENCE OF PALLADIUM CATALYST AND ORGANIC BASE DIRECTOR-GENERAL OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 1997-09-02 US disclosed
JP-H07330909-A NEW POLYMER AND ITS PRODUCTION MITSUBISHI RAYON CO LTD 1995-12-19 JP disclosed
US-5171792-A Crosslinkable saturated and unsaturated carbosilane polymers and formulations UNIVERSITY OF SOUTHERN CALIFORNIA (US) 1992-12-15 US disclosed
US-5130390-A Crosslinkable saturated and unsaturated carbosilane polymers and formulations UNIVERSITY OF SOUTHERN CALIFORNIA (US) 1992-07-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10370588-B2 Organometallic compound and organic light-emitting device including the same L1CAM, AP1M1, L3MBTL1 MAPT 890/4885HPGD 4024/4885SMN1; SMN2 1302/4885
US-20160190484-A1 ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME L1CAM, AP1M1, L3MBTL1 MAPT 890/4885HPGD 4024/4885SMN1; SMN2 1302/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.