Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 14/20 | 0.63 |
| ▸ | HTR1B | P28222 | 14/20 | 0.63 |
| ▸ | HTR1A | P08908 | 4/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | HTR1F | P30939 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR1E | P28566 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764535 | 0.88 | HTR1D (0.64) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL27316732 | 0.86 | HTR1D (0.62) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL9764437 | 0.86 | HTR1D (0.68) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL13234805 | 0.85 | HTR1D (0.69) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| Oxalic Acid SCHEMBL9764572 | 0.83 | HTR1D (0.64) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL23394791 | 0.81 | HTR1D (0.77) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL9764751 | 0.81 | HTR1D (0.65) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9527429 | 0.80 | HTR1D (0.76) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL27455068 | 0.80 | HTR1D (0.55) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL9033732 | 0.80 | HTR1D (0.62) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607960-A | Indole derivatives as 5-HT1-like agonists for use in migraine | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0695301-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-10-30 | — | — | EP | disclosed |
| EP-0695301-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-02-07 | — | — | EP | disclosed |
| WO-1994024127-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |