Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | QPCT | Q16769 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 7/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8915165 | 1.00 | NAMPT (0.52) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8921940 | 0.96 | NAMPT (0.57) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8921935 | 0.96 | NAMPT (0.57) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7430610 | 0.85 | HRH4 (0.52) | NAMPTQPCTKCNJ11 | |
| SCHEMBL8920957 | 0.84 | NAMPT (0.57) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8915411 | 0.82 | NAMPT (0.72) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8918937 | 0.82 | HRH4 (0.48) | NAMPTQPCTNPC1RAB9AKCNJ11 | |
| SCHEMBL8918934 | 0.82 | HRH4 (0.48) | NAMPTQPCTNPC1RAB9AKCNJ11 | |
| SCHEMBL8916138 | 0.81 | NAMPT (0.61) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL810197 | 0.80 | NAMPT (0.63) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696140-A | FOR TREATMENT OF ASTHMA, ALLERGIES, NERVOUS SYSTEM DISORDERS OR CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1997-12-09 | — | — | US | disclosed |
| EP-0660823-B1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS | LEO PHARM PROD LTD (DK) | 1996-08-14 | — | — | EP | disclosed |
| EP-0660823-A1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS. | LEO PHARM PROD LTD (DK) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006770-A1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1994-03-31 | — | — | WO | disclosed |