Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR1B | P28222 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR1F | P30939 | 2/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8914830 | 0.87 | HTR6 (0.53) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8699581 | 0.83 | HTR6 (0.64) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8699573 | 0.83 | HTR6 (0.64) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8546331 | 0.83 | HTR6 (0.55) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8921472 | 0.83 | HTR6 (0.55) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8789712 | 0.82 | HTR6 (0.56) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8789718 | 0.82 | HTR6 (0.56) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8914713 | 0.81 | HTR6 (0.53) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| Hydrochloric Acid SCHEMBL8886514 | 0.81 | HTR6 (0.55) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8915205 | 0.81 | HTR6 (0.53) | HTR6HTR1AHTR1BHTR2CHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607960-A | Indole derivatives as 5-HT1-like agonists for use in migraine | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0695301-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-10-30 | — | — | EP | disclosed |
| CN-1121348-A | Indole derivatives as 5-H1-like agonists for use in migraine | PFIZER RES & DEV (IE) | 1996-04-24 | — | — | CN | disclosed |
| EP-0695301-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-02-07 | — | — | EP | disclosed |
| WO-1994024127-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |