SCHEMBL8915847

CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC=C4CC(OC(=O)CCC(=O)OC[C@@H]5C[C@@H](OP(OCCc6ccc([N+](=O)[O-])cc6)N(C(C)C)C(C)C)[C@H](n6cnc7c(NC(=O)OCCc8ccc([N+](=O)[O-])cc8)ncnc76)O5)CC[C@]4(C)C3CC[C@@]21C

nearest known ligand 0.43

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	PLA2G2A	P14555	1/20	0.41

▸	CYP46A1	Q9Y6A2	2/20	0.39

▸	POLA1	P09884	1/20	0.38

▸	NPC1	O15118	1/20	0.35

▸	NPC1L1	Q9UHC9	4/20	0.35

▸	GBA1	P04062	2/20	0.35

▸	UGCG	Q16739	2/20	0.35

▸	GBA2	Q9HCG7	2/20	0.35

▸	USP2	O75604	1/20	0.34

▸	LMNA	P02545	1/20	0.34

▸	ABCB1	P08183	1/20	0.34

▸	OSBP	P22059	1/20	0.34

▸	RORC	P51449	1/20	0.34

▸	OSBP2	Q969R2	1/20	0.34

▸	NR1H3	Q13133	2/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8912961	0.91	PLA2G2A (0.45)	PLA2G2ACYP46A1POLA1NPC1NPC1L1
SCHEMBL8917330	0.87	POLA1 (0.43)	PLA2G2ACYP46A1POLA1NPC1NPC1L1
SCHEMBL8916895	0.82	POLA1 (0.39)	PLA2G2ACYP46A1POLA1NPC1NPC1L1
SCHEMBL8914377	0.78	POLA1 (0.49)	PLA2G2ACYP46A1POLA1NPC1NPC1L1
SCHEMBL8914667	0.75	PLA2G2A (0.50)	PLA2G2ACYP46A1POLA1NPC1NPC1L1
SCHEMBL8913660	0.75	POLA1 (0.50)	PLA2G2ACYP46A1POLA1NPC1NPC1L1
SCHEMBL8912999	0.72	SLC29A1 (0.40)	—
SCHEMBL8913664	0.72	POLA1 (0.51)	PLA2G2ACYP46A1POLA1NPC1NPC1L1
SCHEMBL8915436	0.72	PLA2G2A (0.49)	PLA2G2ACYP46A1POLA1NPC1NPC1L1
SCHEMBL27084012	0.69	POLA1 (0.59)	PLA2G2ACYP46A1POLA1NPC1NPC1L1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5643889-A	Cholesterol conjugates of 2'5'-oligoadenylate derivatives and antiviral uses thereof	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF PENNSYLVANIA (US)	1997-07-01	—	—	US	disclosed