Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR5A | P47898 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8914633 | 0.88 | SLC22A6 (0.59) | HTR1BHTR1AHTR7HTR6HTR2C | |
| SCHEMBL8915441 | 0.87 | HTR1D (0.45) | HTR1BHTR1AHTR7HTR6HTR2C | |
| SCHEMBL8915816 | 0.87 | PLG (0.43) | HTR1BHTR1AHTR7HTR6HTR2C | |
| SCHEMBL8915273 | 0.87 | HTR1A (0.45) | HTR1BHTR1AHTR7HTR6HTR2C | |
| SCHEMBL8917348 | 0.87 | PLG (0.43) | HTR1BHTR1AHTR7HTR6HTR2C | |
| SCHEMBL8916684 | 0.84 | SLC22A6 (0.44) | HTR1BHTR1AHTR7HTR6HTR2C | |
| SCHEMBL8917363 | 0.84 | KMT2A (0.43) | HTR1BHTR1AHTR7HTR6HTR2C | |
| SCHEMBL8915831 | 0.84 | PARP10 (0.50) | HTR1BHTR1AHTR7HTR6HTR2C | |
| SCHEMBL28842060 | 0.84 | SLC22A6 (0.41) | HTR1BHTR1AHTR7HTR6HTR2C | |
| SCHEMBL8915707 | 0.81 | HTR1B (0.42) | HTR1BHTR1AHTR7HTR6HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703112-A | Method of preventing emesis using tetrahydrobenz CD!indole-6-carbonxamides | ELI LILLY AND COMPANY (US) | 1997-12-30 | — | — | US | disclosed |