Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.49 |
| ▸ | HTR1B | P28222 | 7/20 | 0.49 |
| ▸ | HTR1D | P28221 | 5/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | NOS3 | P29474 | 4/20 | 0.44 |
| ▸ | NOS1 | P29475 | 4/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886632 | 0.87 | HTR6 (0.51) | HTR6HTR1BHTR1DSLC6A4HTR1A | |
| SCHEMBL8886182 | 0.87 | HTR6 (0.49) | HTR6HTR1BHTR1DSLC6A4HTR1A | |
| SCHEMBL8915023 | 0.81 | HTR1B (0.51) | HTR6HTR1BHTR1DHTR1ANOS3 | |
| SCHEMBL8885771 | 0.81 | HTR1B (0.59) | HTR6HTR1BHTR1DSLC6A4HTR1A | |
| Oxalic Acid SCHEMBL2727283 | 0.81 | HTR1B (0.68) | HTR6HTR1BHTR1DHTR1A | |
| Oxalic Acid SCHEMBL2725284 | 0.81 | HTR1B (0.68) | HTR6HTR1BHTR1DHTR1A | |
| SCHEMBL9033153 | 0.81 | HTR1B (0.47) | HTR6HTR1BHTR1DHTR1ANOS3 | |
| SCHEMBL9033149 | 0.81 | HTR1B (0.47) | HTR6HTR1BHTR1DHTR1ANOS3 | |
| SCHEMBL8885806 | 0.81 | SLC6A4 (0.57) | HTR6HTR1BHTR1DSLC6A4HTR1A | |
| SCHEMBL9545605 | 0.79 | HTR1B (0.46) | HTR6HTR1BHTR1DHTR1ANOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607960-A | Indole derivatives as 5-HT1-like agonists for use in migraine | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0695301-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-10-30 | — | — | EP | disclosed |
| WO-1994024127-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |