Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | ATM | Q13315 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RGS12 | O14924 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8670276 | 0.76 | MEN1 (0.58) | KMT2AMEN1NPC1ATMRAB9A | |
| SCHEMBL9064445 | 0.68 | MEN1 (0.83) | KMT2AMEN1NPC1ATMRAB9A | |
| SCHEMBL3363229 | 0.68 | MEN1 (0.83) | KMT2AMEN1NPC1ATMRAB9A | |
| SCHEMBL8651550 | 0.68 | MEN1 (0.83) | KMT2AMEN1NPC1ATMRAB9A | |
| SCHEMBL8007458 | 0.66 | MEN1 (0.86) | KMT2AMEN1NPC1ATMRAB9A | |
| Dodecane SCHEMBL27596710 | 0.66 | NPC1 (0.50) | KMT2AMEN1NPC1ATMRAB9A | |
| Acridine SCHEMBL8920746 | 0.66 | TLR8 (0.44) | KMT2AMEN1SMN1; SMN2NPSR1MAPK1 | |
| SCHEMBL10361949 | 0.64 | MAPT (0.45) | KMT2AMEN1NPC1ATMKDM4E | |
| Tetradecane SCHEMBL9931457 | 0.63 | HTT (0.57) | KMT2AMEN1NPC1ATMRAB9A | |
| Naphthalene SCHEMBL11775581 | 0.63 | HTT (0.57) | KMT2AMEN1NPC1ATMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665328-A | USING SELECTED DYE AS BINDING AGENT WITHOUT PRODUCING DETRIMENTAL EFFECT ON MORPHOLOGY OR PHYSIOLOGICAL FUNCTION OF CELLS | PHANOS TECHNOLOGIES, INC. (US) | 1997-09-09 | — | — | US | claimed |
| EP-0430968-A4 | COMPOUNDS, COMPOSITIONS AND METHOD FOR BINDING BIO-AFFECTING SUBSTANCES TO SURFACE MEMBRANES OF BIO-PARTICLES | — | 1993-10-20 | — | — | EP | claimed |
| EP-0430968-A1 | COMPOUNDS, COMPOSITIONS AND METHOD FOR BINDING BIO-AFFECTING SUBSTANCES TO SURFACE MEMBRANES OF BIO-PARTICLES. | ZYNAXIS TECHNOLOGIES INC (US) | 1991-06-12 | — | — | EP | claimed |
| WO-1989010758-A1 | COMPOUNDS, COMPOSITIONS AND METHOD FOR BINDING BIO-AFFECTING SUBSTANCES TO SURFACE MEMBRANES OF BIO-PARTICLES | ZYNAXIS TECHNOLOGIES, INC. (US) | 1989-11-16 | — | — | WO | claimed |
| US-5665328-A | USING SELECTED DYE AS BINDING AGENT WITHOUT PRODUCING DETRIMENTAL EFFECT ON MORPHOLOGY OR PHYSIOLOGICAL FUNCTION OF CELLS | PHANOS TECHNOLOGIES, INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0430968-B1 | COMPOUNDS, COMPOSITIONS AND METHOD FOR BINDING BIO-AFFECTING SUBSTANCES TO SURFACE MEMBRANES OF BIO-PARTICLES | PHANOS TECH INC (US) | 1996-11-20 | — | — | EP | disclosed |
| EP-0430968-A4 | COMPOUNDS, COMPOSITIONS AND METHOD FOR BINDING BIO-AFFECTING SUBSTANCES TO SURFACE MEMBRANES OF BIO-PARTICLES | — | 1993-10-20 | — | — | EP | disclosed |
| EP-0430968-A1 | COMPOUNDS, COMPOSITIONS AND METHOD FOR BINDING BIO-AFFECTING SUBSTANCES TO SURFACE MEMBRANES OF BIO-PARTICLES. | ZYNAXIS TECHNOLOGIES INC (US) | 1991-06-12 | — | — | EP | disclosed |
| WO-1989010758-A1 | COMPOUNDS, COMPOSITIONS AND METHOD FOR BINDING BIO-AFFECTING SUBSTANCES TO SURFACE MEMBRANES OF BIO-PARTICLES | ZYNAXIS TECHNOLOGIES, INC. (US) | 1989-11-16 | — | — | WO | disclosed |