Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | ATM | Q13315 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | HTT | P42858 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 2/20 | 0.42 |
| ▸ | RGS12 | O14924 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9065129 | 0.83 | MEN1 (0.50) | MEN1KMT2ANPC1ATMRAB9A | |
| SCHEMBL3363229 | 0.77 | MEN1 (0.83) | MEN1KMT2ANPC1ATMRAB9A | |
| SCHEMBL8651550 | 0.77 | MEN1 (0.83) | MEN1KMT2ANPC1ATMRAB9A | |
| SCHEMBL9064445 | 0.77 | MEN1 (0.83) | MEN1KMT2ANPC1ATMRAB9A | |
| SCHEMBL2462923 | 0.77 | MEN1 (0.83) | MEN1KMT2ANPC1ATMRAB9A | |
| Iodide SCHEMBL8917096 | 0.76 | KMT2A (0.49) | MEN1KMT2ANPC1ATMRAB9A | |
| SCHEMBL8007458 | 0.75 | MEN1 (0.86) | MEN1KMT2ANPC1ATMRAB9A | |
| Iodide SCHEMBL17423284 | 0.72 | MEN1 (1.00) | MEN1KMT2ANPC1ATMRAB9A | |
| Iodide SCHEMBL8920749 | 0.69 | MEN1 (0.63) | MEN1KMT2ANPC1ATMRAB9A | |
| SCHEMBL27561681 | 0.68 | MEN1 (0.83) | MEN1KMT2ANPC1ATMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990002334-A1 | REAGENTS AND METHODS FOR DETERMINATION OF ANALYTES | ZYNAXIS TECHNOLOGIES, INC. (US) | 1990-03-08 | — | — | WO | claimed |
| EP-0471792-B1 | METHODS, REAGENTS AND TEST KITS FOR DETERMINATION OF SUBPOPULATIONS OF BIOLOGICAL ENTITIES | INTRACEL CORP (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5375606-A | Injecting microspheres coupled to bioaffecting compound having detectable moiety, measuring microspheres in volume of blood withdrawn, recovering tissue, extracting compound, measuring intensity, correlating to microspheres, calculating blood flow | ZYNAXIS, INC. (US) | 1994-12-27 | — | — | US | disclosed |
| US-5256532-A | Coupling analyte to detectable reporter substance | ZYNAXIS TECHNOLOGIES, INC. (US) | 1993-10-26 | — | — | US | disclosed |
| EP-0471792-A4 | METHODS, REAGENTS AND TEST KITS FOR DETERMINATION OF SUBPOPULATIONS OF BIOLOGICAL ENTITIES | — | 1992-09-16 | — | — | EP | disclosed |
| EP-0471792-A1 | METHODS, REAGENTS AND TEST KITS FOR DETERMINATION OF SUBPOPULATIONS OF BIOLOGICAL ENTITIES | Zynaxis Inc. (US) | 1992-02-26 | — | — | EP | disclosed |
| WO-1990014435-A1 | METHODS, REAGENTS AND TEST KITS FOR DETERMINATION OF SUBPOPULATIONS OF BIOLOGICAL ENTITIES | ZYNAXIS TECHNOLOGIES, INC. (US) | 1990-11-29 | — | — | WO | disclosed |
| WO-1990002334-A1 | REAGENTS AND METHODS FOR DETERMINATION OF ANALYTES | ZYNAXIS TECHNOLOGIES, INC. (US) | 1990-03-08 | — | — | WO | disclosed |