Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 10/20 | 0.52 |
| ▸ | HTR7 | P34969 | 9/20 | 0.52 |
| ▸ | DRD2 | P14416 | 9/20 | 0.52 |
| ▸ | HTR6 | P50406 | 8/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917040 | 0.85 | ACHE (0.59) | ACHEHTR2AHTR7DRD2HTR6 | |
| SCHEMBL8918516 | 0.84 | DRD2 (0.58) | ACHEHTR2AHTR7DRD2HTR6 | |
| SCHEMBL8917433 | 0.84 | ACHE (0.54) | ACHEHTR2ADRD2HTR2CSLC6A4 | |
| SCHEMBL8917216 | 0.84 | DRD2 (0.57) | ACHEHTR2ADRD2HTR6KCNH2 | |
| SCHEMBL8918416 | 0.83 | HTR2A (0.53) | ACHEHTR2AHTR7DRD2HTR6 | |
| SCHEMBL8920476 | 0.83 | ACHE (0.52) | ACHEHTR2ADRD2HTR2CSLC6A4 | |
| SCHEMBL8916506 | 0.80 | ACHE (0.52) | ACHEHTR2AHTR7DRD2HTR6 | |
| SCHEMBL8920609 | 0.77 | DRD2 (0.59) | ACHEHTR2AHTR7DRD2HTR6 | |
| Hydrochloric Acid SCHEMBL8916425 | 0.76 | DRD2 (0.58) | ACHEHTR2AHTR7DRD2HTR6 | |
| SCHEMBL8917553 | 0.76 | DRD2 (0.55) | ACHEHTR2AHTR7DRD2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691330-A | ANTIPSYCHOTIC AGENT | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-11-25 | — | — | US | disclosed |
| US-5532240-A | ANTIPSYCHOTIC AGENTS AND ANTISEROTONIN AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0596125-A1 | CONDENSED THIOPHENE COMPOUND AND PHARMACEUTICAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-05-11 | — | — | EP | disclosed |