Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28261011 | 0.86 | TSHR (0.41) | MAPTALDH1A1TSHRTDP1GRIN2D | |
| SCHEMBL670917 | 0.80 | TSHR (0.58) | ALDH1A1TSHRTDP1GRIN2DGRIN3B | |
| SCHEMBL28113776 | 0.79 | ALDH1A1 (0.67) | MAPTALDH1A1TSHRTDP1CA12 | |
| SCHEMBL21543104 | 0.78 | MAPT (0.44) | MAPTALDH1A1TSHRTDP1CA12 | |
| SCHEMBL27363125 | 0.78 | MAPT (0.44) | MAPTALDH1A1TSHRTDP1CA12 | |
| SCHEMBL30870615 | 0.78 | MAPT (0.44) | MAPTALDH1A1TSHRTDP1CA12 | |
| SCHEMBL10193193 | 0.76 | TDP1 (0.50) | MAPTALDH1A1TSHRTDP1CA12 | |
| SCHEMBL541489 | 0.75 | TDP1 (0.72) | ALDH1A1TSHRTDP1GRIN2DGRIN3B | |
| SCHEMBL11569768 | 0.75 | TSHR (0.43) | ALDH1A1TSHRTDP1GRIN2DGRIN3B | |
| SCHEMBL6786619 | 0.74 | TDP1 (0.48) | MAPTALDH1A1TSHRTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668136-A | ANTIARTERIOSCLEROTIC AGENT, CHOLESTEROL O-ACYLTRANSFERASE INHIBITOR | EISAI CO., LTD. (JP) | 1997-09-16 | — | — | US | disclosed |
| EP-0477778-B1 | Benzene, pyridine and pyrimidine derivative | EISAI CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0615970-A1 | Benzene, pyridine and pyrimidine derivative | Eisai Co., Ltd. (JP) | 1994-09-21 | — | — | EP | disclosed |
| EP-0477778-A2 | Benzene, pyridine and pyrimidine derivative | Eisai Co., Ltd. (JP) | 1992-04-01 | — | — | EP | disclosed |