Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 5/20 | 0.50 |
| ▸ | CYP24A1 | Q07973 | 3/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916715 | 0.81 | MIF (0.50) | MIFCYP24A1CYP26A1KDM4EGLA | |
| SCHEMBL6793591 | 0.80 | MIF (0.52) | MIFCYP24A1CYP26A1KDM4EGLA | |
| SCHEMBL6793599 | 0.80 | MIF (0.52) | MIFCYP24A1CYP26A1KDM4EGLA | |
| SCHEMBL8918866 | 0.76 | CES1 (0.55) | MIFALDH1A1MAPTCYP19A1 | |
| SCHEMBL12046659 | 0.75 | KDM4E (0.50) | MIFCYP24A1CYP26A1KDM4EGLA | |
| SCHEMBL17108416 | 0.73 | MPO (0.59) | MIFCYP26A1KDM4EGLAALDH1A1 | |
| SCHEMBL11684649 | 0.72 | KDM4E (0.57) | MIFCYP26A1KDM4EGLAMAPK14 | |
| SCHEMBL268592 | 0.72 | KDM4E (0.56) | MIFCYP26A1KDM4EGLAALDH1A1 | |
| SCHEMBL3759572 | 0.71 | MAPK14 (0.64) | MIFCYP24A1CYP26A1KDM4EMAPK14 | |
| SCHEMBL7665423 | 0.71 | CYP1A2 (0.48) | MIFCYP24A1CYP26A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696143-A | ARTHRITIS THERAPY | G.D. SEARLE & CO. | 1997-12-09 | — | — | US | disclosed |
| WO-1996009293-A1 | BENZ[g]INDAZOLYL DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-28 | — | — | WO | disclosed |