Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.49 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | QPCT | Q16769 | 1/20 | 0.46 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.46 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99122 | 0.95 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP17A1CYP19A1CYP1A2 | |
| SCHEMBL3168682 | 0.80 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP19A1CYP1A2CYP3A4 | |
| SCHEMBL11013739 | 0.78 | TDP1 (0.47) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL28179425 | 0.75 | TDP1 (0.53) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL8497604 | 0.75 | CYP19A1 (0.45) | CYP11B1CYP11B2CYP19A1POLBMEN1 | |
| SCHEMBL21104644 | 0.74 | CYP11B1 (0.44) | CYP11B1CYP11B2CYP17A1CYP19A1CYP1A2 | |
| SCHEMBL27792150 | 0.72 | TSHR (0.50) | CYP1A2KMT2AALOX15TSHRLMNA | |
| Biphenyl SCHEMBL27540403 | 0.71 | MEN1 (0.46) | CYP11B1CYP11B2CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL17315100 | 0.71 | CYP19A1 (0.46) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL12682673 | 0.71 | IDO1 (0.46) | CYP11B1CYP11B2CYP19A1CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674879-A | Compositions including and methods of using conformationally restricted angiotensin II antagonist | G.D. SEARLE & CO. (US) | 1997-10-07 | — | — | US | disclosed |