Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99122 | 0.84 | CYP11B1 (0.50) | CYP11B1CYP19A1CYP11B2CYP3A4CYP2D6 | |
| Biphenyl SCHEMBL8917652 | 0.80 | CYP11B1 (0.49) | CYP11B1CYP19A1CYP11B2CYP3A4CYP2D6 | |
| SCHEMBL3179446 | 0.74 | CYP11B1 (0.38) | CYP11B1CYP19A1CYP11B2CYP2D6CYP2A6 | |
| SCHEMBL493020 | 0.72 | CYP1A2 (0.56) | CYP2D6CYP2A6CYP1A2CHRNB2CHRNA4 | |
| SCHEMBL7546085 | 0.71 | CHRNB2 (0.57) | CYP2D6CYP1A2CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL11013739 | 0.71 | TDP1 (0.47) | CYP11B1CYP19A1CYP11B2CYP3A4CYP2D6 | |
| SCHEMBL12682673 | 0.71 | IDO1 (0.46) | CYP11B1CYP19A1CYP11B2CYP2D6IDO1 | |
| SCHEMBL1622205 | 0.71 | CYP11B1 (0.50) | CYP11B1CYP19A1CYP11B2CYP3A4CYP2D6 | |
| SCHEMBL570582 | 0.70 | CYP11B1 (1.00) | CYP11B1CYP19A1CYP11B2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL27794086 | 0.70 | CYP1A2 (0.54) | CYP2D6CYP2A6CYP1A2CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100010049-A1 | Novel Tyrosinase inhibitors and pharmaceutical/cosmetic applications thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-01-14 | — | — | US | disclosed |
| EP-2041095-A1 | NOVEL TYROSINASE INHIBITORS, THEIR PROCESS OF PREPARATION AND THEIR USE IN HUMAN MEDICINE AND IN COSMETICS | Galderma Research & Development (FR) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008006824-A1 | NOVEL TYROSINASE INHIBITORS, THEIR PROCESS OF PREPARATION AND THEIR USE IN HUMAN MEDICINE AND IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010049-A1 | Novel Tyrosinase inhibitors and pharmaceutical/cosmetic applications thereof | TYR, MITF, MAOA | CYP11B1 759/4885CYP19A1 46/4885CYP11B2 795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.