Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 7/20 | 0.47 |
| ▸ | CA2 | P00918 | 7/20 | 0.47 |
| ▸ | CA9 | Q16790 | 7/20 | 0.47 |
| ▸ | CA4 | P22748 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.46 |
| ▸ | CA12 | O43570 | 5/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917535 | 0.91 | LCK (0.40) | CA1CA2CA9CA4PTGS2 | |
| SCHEMBL8918143 | 0.88 | PTGS2 (0.54) | CA1CA2CA9CA4PTGS2 | |
| SCHEMBL8918086 | 0.84 | PTGS2 (0.48) | CA1CA2CA9CA4PTGS2 | |
| SCHEMBL9232444 | 0.84 | PTGS2 (0.54) | CA1CA2CA9PTGS2PTGS1 | |
| SCHEMBL9235959 | 0.83 | PTGS2 (0.53) | CA1CA2CA9CA4PTGS2 | |
| SCHEMBL9231983 | 0.82 | PTGS2 (0.43) | CA9PTGS2PTGS1 | |
| SCHEMBL9231444 | 0.81 | PTGS2 (0.44) | CA1CA2PTGS2PTGS1 | |
| SCHEMBL9229656 | 0.80 | PTGS2 (0.45) | CA1CA2CA9PTGS2CA12 | |
| SCHEMBL9233935 | 0.80 | PTGS2 (0.52) | PTGS2PTGS1 | |
| SCHEMBL8917212 | 0.80 | PTGS2 (0.42) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696143-A | ARTHRITIS THERAPY | G.D. SEARLE & CO. | 1997-12-09 | — | — | US | disclosed |