Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.42 |
| ▸ | RARG | P13631 | 6/20 | 0.42 |
| ▸ | RARA | P10276 | 5/20 | 0.42 |
| ▸ | RARB | P10826 | 5/20 | 0.42 |
| ▸ | RXRA | P19793 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918143 | 0.89 | PTGS2 (0.54) | PTGS2KMT2AALOX5 | |
| SCHEMBL8917535 | 0.89 | LCK (0.40) | PTGS2RARGKDM4EALDH1A1AOC3 | |
| SCHEMBL8917466 | 0.86 | PTGS2 (0.41) | PTGS2ALOX5AOC3 | |
| SCHEMBL8917301 | 0.85 | PTGS2 (0.45) | PTGS2ALOX5 | |
| SCHEMBL8916673 | 0.84 | PTGS2 (0.44) | PTGS2ALOX5AOC3 | |
| SCHEMBL8917700 | 0.84 | CYP1A2 (0.47) | PTGS2RARGRARARARBRXRA | |
| SCHEMBL8916712 | 0.84 | PTGS2 (0.41) | PTGS2ALOX5 | |
| SCHEMBL8919630 | 0.84 | PTGS2 (0.44) | PTGS2 | |
| SCHEMBL8917475 | 0.83 | PTGS2 (0.46) | PTGS2ALOX5 | |
| SCHEMBL8919075 | 0.83 | PTGS2 (0.40) | PTGS2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696143-A | ARTHRITIS THERAPY | G.D. SEARLE & CO. | 1997-12-09 | — | — | US | disclosed |