Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 10/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 8/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | TACR2 | P21452 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421925 | 0.86 | FFAR1 (0.34) | SPHK1LMNAKDM4EALDH1A1CHRM5 | |
| SCHEMBL8707234 | 0.73 | HRH3 (0.37) | KDM4ETP53 | |
| SCHEMBL8920052 | 0.72 | KMT2A (0.53) | LMNATSHRKDM4EALDH1A1CYP3A4 | |
| SCHEMBL9328232 | 0.70 | HSD17B10 (0.61) | LMNAHSD17B10TSHRESR1ADRA2A | |
| SCHEMBL8433963 | 0.70 | HSD17B10 (0.61) | LMNAHSD17B10TSHRESR1ADRA2A | |
| SCHEMBL9497770 | 0.69 | FFAR1 (0.48) | SPHK1MMP2MMP9MMP8MMP13 | |
| SCHEMBL9497780 | 0.69 | FFAR1 (0.48) | SPHK1MMP2MMP9MMP8MMP13 | |
| SCHEMBL9497787 | 0.69 | FFAR1 (0.48) | SPHK1MMP2MMP9MMP8MMP13 | |
| SCHEMBL9496811 | 0.68 | FFAR1 (0.47) | SPHK1MMP2MMP9MMP8MMP13 | |
| SCHEMBL9496944 | 0.68 | FFAR1 (0.47) | SPHK1LMNAHSD17B10TSHRESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691349-A | ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 1997-11-25 | — | — | US | claimed |
| US-5691349-A | ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 1997-11-25 | — | — | US | disclosed |