Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8918396 | 0.91 | ALDH1A1 (0.34) | NPC1CASP3RAB9ASENP8SENP7 | |
| Hydrochloric Acid SCHEMBL7940441 | 0.87 | NPC1 (0.34) | NPC1CASP3RAB9ASENP8SENP7 | |
| Hydrochloric Acid SCHEMBL540419 | 0.83 | ALDH1A1 (0.41) | NPC1CASP3RAB9ASENP8SENP7 | |
| Hydrochloric Acid SCHEMBL5346997 | 0.82 | ALDH1A1 (0.45) | NPC1CASP3RAB9ASENP8SENP7 | |
| Hydrochloric Acid SCHEMBL5352654 | 0.81 | HTR2A (0.47) | ALDH1A1HTR2APDE10A | |
| Hydrochloric Acid SCHEMBL5353788 | 0.79 | ALDH1A1 (0.45) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL27336773 | 0.79 | ALDH1A1 (0.47) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL7626874 | 0.79 | ALDH1A1 (0.47) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL7605735 | 0.77 | ALDH1A1 (0.46) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL7607194 | 0.77 | ALDH1A1 (0.46) | NPC1CASP3RAB9ASENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668230-A | METALLOCENE WITH ETHYLENE BRIDGED FLUORENE UNITS, ALUMOXANE COCATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1997-09-16 | — | — | US | claimed |