Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918568 | 1.00 | MTNR1A (0.35) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL8920205 | 0.85 | MTNR1A (0.33) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL8920203 | 0.85 | MTNR1A (0.33) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL8919531 | 0.81 | MTNR1A (0.37) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL8919535 | 0.81 | MTNR1A (0.37) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL8919742 | 0.79 | XPO1 (0.35) | MTNR1AMTNR1B | |
| SCHEMBL8919747 | 0.79 | XPO1 (0.35) | MTNR1AMTNR1B | |
| SCHEMBL20334417 | 0.76 | ALDH1A1 (0.36) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL20334581 | 0.73 | KDM4E (0.39) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL7029874 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691366-A | UNSATURATED NITRO OXIME FORMED BY REACTION OF DINITROGEN TRIOXIDE WITH DIOLEFIN ETHER, SULFIDE OR AMINE TO BE USED AS VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-11-25 | — | — | US | disclosed |
| US-5495023-A | VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-27 | — | — | US | disclosed |
| EP-0612315-A1 | NITRO COMPOUNDS HAVING VASODILATOR ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993010097-A1 | NITRO COMPOUNDS HAVING VASODILATOR ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-27 | — | — | WO | disclosed |