Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 13/20 | 0.48 |
| ▸ | HRH2 | P25021 | 9/20 | 0.48 |
| ▸ | HRH1 | P35367 | 5/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916216 | 0.99 | HRH4 (0.48) | HRH4HRH2HRH1HRH3CYP1A2 | |
| SCHEMBL8915041 | 0.91 | HRH4 (0.53) | HRH4HRH2HRH1HRH3CYP1A2 | |
| SCHEMBL8918620 | 0.85 | MAPT (0.45) | HRH4HRH2HRH1HRH3HDAC3 | |
| SCHEMBL504459 | 0.83 | CYP3A4 (0.47) | HRH4HRH2HRH3CYP3A4CYP2D6 | |
| SCHEMBL504267 | 0.83 | CYP3A4 (0.47) | HRH4HRH2HRH3CYP3A4CYP2D6 | |
| SCHEMBL8054318 | 0.83 | CYP3A4 (0.47) | HRH4HRH2HRH3CYP3A4CYP2D6 | |
| SCHEMBL504467 | 0.83 | CYP3A4 (0.47) | HRH4HRH2HRH3CYP3A4CYP2D6 | |
| SCHEMBL504458 | 0.83 | CYP3A4 (0.47) | HRH4HRH2HRH3CYP3A4CYP2D6 | |
| SCHEMBL8054097 | 0.83 | CYP3A4 (0.47) | HRH4HRH2HRH3CYP3A4CYP2D6 | |
| SCHEMBL504466 | 0.83 | CYP3A4 (0.47) | HRH4HRH2HRH3CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696140-A | FOR TREATMENT OF ASTHMA, ALLERGIES, NERVOUS SYSTEM DISORDERS OR CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1997-12-09 | — | — | US | disclosed |