SCHEMBL8915041

SCHEMBL8915041

N#CNC(=Nc1ccncc1)NCCSc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 9/20 0.53
HRH2 P25021 7/20 0.53
HRH1 P35367 5/20 0.53
HRH3 Q9Y5N1 5/20 0.53
RAB9A P51151 6/20 0.43
NPC1 O15118 5/20 0.43
SMN1; SMN2 Q16637 5/20 0.43
ALDH1A1 P00352 3/20 0.43
MTNR1A P48039 1/20 0.42
MTNR1B P49286 1/20 0.42
RECQL P46063 1/20 0.41
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
HIF1A Q16665 1/20 0.40
HPGD P15428 3/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8916216 0.92 HRH4 (0.48) HRH4HRH2HRH1HRH3RAB9A
SCHEMBL8918930 0.91 HRH4 (0.48) HRH4HRH2HRH1HRH3ALDH1A1
SCHEMBL8915477 0.87 HRH4 (0.53) HRH4HRH2HRH1HRH3RAB9A
SCHEMBL8919392 0.81 HRH4 (0.48) HRH4RAB9ANPC1SMN1; SMN2MTNR1A
SCHEMBL8920080 0.80 NAMPT (0.40) HRH4HRH2ALDH1A1CYP1A2CYP3A4
SCHEMBL8915410 0.80 HRH4 (0.45) HRH4HRH2MTNR1AMTNR1BRECQL
SCHEMBL8195916 0.80 HRH4 (0.36) HRH4HRH2HRH1HRH3SMN1; SMN2
SCHEMBL8195910 0.80 HRH4 (0.36) HRH4HRH2HRH1HRH3SMN1; SMN2
SCHEMBL6950781 0.79 CYP3A4 (0.46) HRH4HRH2HRH3RECQLCYP3A4
SCHEMBL11157133 0.78 NAMPT (0.49) SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5696140-A FOR TREATMENT OF ASTHMA, ALLERGIES, NERVOUS SYSTEM DISORDERS OR CANCER LEO PHARMACEUTICAL PRODUCTS LTD. (DK) 1997-12-09 US disclosed
US-5563160-A NERVOUS SYSTEM DISORDERS, ANTIHISTAMINE, ANTIALLERGENS Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktieselskab) (DK) 1996-10-08 US disclosed
EP-0660823-B1 N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS LEO PHARM PROD LTD (DK) 1996-08-14 EP disclosed
EP-0660823-A1 N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS. LEO PHARM PROD LTD (DK) 1995-07-05 EP disclosed
WO-1994006770-A1 N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 1994-03-31 WO disclosed