Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8698025 | 0.80 | LMNA (0.37) | LMNAALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL1838079 | 0.77 | LMNA (0.50) | LMNAALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL1129750 | 0.77 | CYP3A4 (0.49) | LMNAALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL5513814 | 0.76 | LTA4H (0.39) | LMNAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1835893 | 0.76 | LMNA (0.49) | LMNAALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL31112984 | 0.76 | LMNA (0.49) | LMNAALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL1837124 | 0.75 | LMNA (0.47) | LMNAALDH1A1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL9789773 | 0.75 | SMN1; SMN2 (0.42) | LMNAALDH1A1SMN1; SMN2GAACYP3A4 | |
| SCHEMBL2502300 | 0.74 | NPC1 (0.43) | LMNAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1838269 | 0.72 | LMNA (0.45) | LMNAALDH1A1SMN1; SMN2CYP3A4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |