Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8399414 | 0.90 | ALDH1A1 (0.44) | MEN1KMT2ATP53ALDH1A1ALDH2 | |
| SCHEMBL8923872 | 0.84 | ATM (0.45) | MEN1KMT2ATP53GAAATM | |
| SCHEMBL8920778 | 0.84 | MAPT (0.42) | MEN1KMT2AALDH1A1CYP19A1DDB1 | |
| SCHEMBL8400979 | 0.83 | DDB1 (0.45) | MEN1KMT2AALDH1A1DDB1CRBN | |
| SCHEMBL8398575 | 0.81 | THRB (0.42) | MEN1KMT2AALDH1A1ALDH2SLC6A2 | |
| SCHEMBL8921539 | 0.78 | DDB1 (0.55) | MEN1KMT2ATP53GAAALDH1A1 | |
| SCHEMBL12559670 | 0.78 | TDP1 (0.57) | MEN1KMT2ATP53GAAALDH1A1 | |
| SCHEMBL8398580 | 0.76 | SLC6A2 (0.43) | TP53ALDH1A1CYP19A1SLC6A2SLC6A4 | |
| SCHEMBL18025749 | 0.76 | BRD4 (0.57) | MEN1KMT2ATP53GAAATM | |
| SCHEMBL8402167 | 0.75 | DDB1 (0.47) | MEN1KMT2ATP53ALDH1A1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |