Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | LOX | P28300 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11059721 | 0.99 | HRH3 (0.47) | HRH3PRMT6ALDH1A1HTTTSHR | |
| SCHEMBL8918275 | 0.96 | HRH3 (0.48) | HRH3PRMT6ALDH1A1HTTTSHR | |
| SCHEMBL8920024 | 0.95 | HRH3 (0.47) | HRH3PRMT6ALDH1A1HTTTSHR | |
| SCHEMBL9838916 | 0.84 | HRH3 (0.47) | HRH3ALDH1A1HTTTSHRACHE | |
| SCHEMBL10541348 | 0.83 | HRH3 (0.46) | HRH3ALDH1A1HTTTSHRACHE | |
| SCHEMBL10988041 | 0.81 | HRH3 (0.50) | HRH3TSHRACHERAD52ELOVL1 | |
| SCHEMBL8078636 | 0.80 | ADRA2C (0.52) | HRH3PRMT6ALDH1A1HTTCXCR4 | |
| SCHEMBL8078640 | 0.80 | ADRA2C (0.52) | HRH3PRMT6ALDH1A1HTTCXCR4 | |
| SCHEMBL10375950 | 0.80 | LOX (0.54) | HRH3ALDH1A1HTTTSHRCXCR4 | |
| SCHEMBL10375949 | 0.80 | HRH3 (0.47) | HRH3PRMT6ALDH1A1HTTCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616579-A | ADMINISTERING TO MAMMALS TO PREVENT GASTRIC ULCER | SANKYO COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0562833-B1 | Anti-ulcer pyridyloxy derivatives, their preparation and uses | SANKYO CO (JP) | 1996-05-08 | — | — | EP | disclosed |
| EP-0562833-A1 | Anti-ulcer pyridyloxy derivatives, their preparation and uses | SANKYO COMPANY LIMITED (JP) | 1993-09-29 | — | — | EP | disclosed |
| EP-0117345-B1 | AMINOPYRIMIDINONES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-28 | — | — | EP | disclosed |
| EP-0134096-B1 | AMINOPYRIMIDINONE DERIVATIVES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-01 | — | — | EP | disclosed |
| US-4772704-A | ANTIULCER AGENTS | BRISTOL-MYERS COMPANY (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0132914-B1 | IMIDAZOLINONE DERIVATIVES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-06-08 | — | — | EP | disclosed |
| US-4600779-A | Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity | BRISTOL-MYERS COMPANY (US) | 1986-07-15 | — | — | US | disclosed |
| US-4595758-A | Containing thienyl ring | BRISTOL-MYERS COMPANY (US) | 1986-06-17 | — | — | US | disclosed |
| EP-0105703-B1 | DIOXOCYCLOBUTENE COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-05-28 | — | — | EP | disclosed |
| US-4514408-A | INHIBITORS OF GASTRIC SECRETION | SANOFI (FR) | 1985-04-30 | — | — | US | disclosed |
| EP-0134096-A2 | Aminopyrimidinone derivatives as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-03-13 | — | — | EP | disclosed |
| EP-0132914-A2 | Imidazolinone derivatives as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-02-13 | — | — | EP | disclosed |
| WO-1984004304-A1 | AMINOIMIDAZOLONE DERIVATIVES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE FRENCH LAB (GB) | 1984-11-08 | — | — | WO | disclosed |
| EP-0117345-A2 | Aminopyrimidinones as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-09-05 | — | — | EP | disclosed |
| US-4466970-A | ANTIHISTAMINE, ANTIULCER AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-08-21 | — | — | US | disclosed |
| EP-0105703-A1 | Dioxocyclobutene compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-04-18 | — | — | EP | disclosed |
| US-4440933-A | HISTAMINE H2-RECEPTOR ANTAGONISTS | BRISTOL-MYERS COMPANY (US) | 1984-04-03 | — | — | US | disclosed |
| EP-0103503-A2 | N-substituted amides, their salts, process for their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1984-03-21 | — | — | EP | disclosed |
| EP-0101380-A2 | N-substituted nicotinamide-1-oxide, its salts, process for their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1984-02-22 | — | — | EP | disclosed |