SCHEMBL8920050

SCHEMBL8920050

Brc1ccc2c(c1Br)c1ccccc1n2Cc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.61
P2RX4 Q99571 2/20 0.54
UTS2R Q9UKP6 1/20 0.44
KMT2A Q03164 5/20 0.44
LMNA P02545 2/20 0.44
SMN1; SMN2 Q16637 3/20 0.43
MEN1 O00255 3/20 0.43
MAPK1 P28482 3/20 0.43
KDM4E B2RXH2 1/20 0.43
ALDH1A1 P00352 1/20 0.43
MAPT P10636 1/20 0.43
HDAC6 Q9UBN7 2/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC10 Q969S8 1/20 0.42
PGR P06401 1/20 0.42
SRC P12931 1/20 0.41
CYP1B1 Q16678 1/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16186875 0.78 CYP19A1 (0.65) CYP19A1P2RX4UTS2RKMT2ALMNA
SCHEMBL151053 0.77 CYP19A1 (1.00) CYP19A1P2RX4KMT2ALMNASMN1; SMN2
SCHEMBL30007452 0.77 CYP19A1 (1.00) CYP19A1P2RX4KMT2ALMNASMN1; SMN2
Bromide SCHEMBL28888744 0.75 CYP19A1 (0.95) CYP19A1P2RX4KMT2ALMNASMN1; SMN2
Ammonia Solution, Strong SCHEMBL29210102 0.75 CYP19A1 (0.95) CYP19A1P2RX4KMT2ALMNASMN1; SMN2
SCHEMBL9398256 0.75 CYP19A1 (0.95) CYP19A1P2RX4KMT2ALMNASMN1; SMN2
SCHEMBL30234033 0.74 CYP19A1 (0.70) CYP19A1P2RX4KMT2ALMNASMN1; SMN2
SCHEMBL17439171 0.74 CYP19A1 (0.70) CYP19A1P2RX4KMT2ALMNASMN1; SMN2
SCHEMBL6921173 0.74 CYP19A1 (0.65) CYP19A1P2RX4UTS2RKMT2ALMNA
SCHEMBL2246814 0.74 CYP19A1 (0.70) CYP19A1P2RX4KMT2ASMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-9118664-A None JP disclosed
JP-H09118664-A CARBAZOLE-BASED POLYAMIDE AND ITS PRODUCTION AGENCY OF IND SCIENCE & TECHNOL 1997-05-06 JP disclosed