Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920048 | 1.00 | ALDH1A1 (0.53) | ALDH1A1TDP1TSHRRAB9AMAPT | |
| SCHEMBL10613251 | 0.86 | MAPT (0.58) | ALDH1A1TDP1TSHRRAB9AMAPT | |
| SCHEMBL10341377 | 0.86 | MAPT (0.58) | ALDH1A1TDP1TSHRRAB9AMAPT | |
| SCHEMBL16956500 | 0.77 | ALDH1A1 (0.64) | ALDH1A1TDP1TSHRMAPTMEN1 | |
| SCHEMBL6421785 | 0.77 | ALDH1A1 (0.48) | ALDH1A1TSHRRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7069601 | 0.77 | ALDH1A1 (0.48) | ALDH1A1TSHRRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6421789 | 0.77 | ALDH1A1 (0.48) | ALDH1A1TSHRRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL722136 | 0.75 | ALDH1A1 (0.67) | ALDH1A1TDP1TSHRMAPTMEN1 | |
| SCHEMBL11836212 | 0.75 | ALDH1A1 (0.56) | ALDH1A1TDP1TSHRRAB9AMAPT | |
| SCHEMBL11836225 | 0.75 | ALDH1A1 (0.56) | ALDH1A1TDP1TSHRRAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668136-A | ANTIARTERIOSCLEROTIC AGENT, CHOLESTEROL O-ACYLTRANSFERASE INHIBITOR | EISAI CO., LTD. (JP) | 1997-09-16 | — | — | US | disclosed |
| EP-0477778-B1 | Benzene, pyridine and pyrimidine derivative | EISAI CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0615970-A1 | Benzene, pyridine and pyrimidine derivative | Eisai Co., Ltd. (JP) | 1994-09-21 | — | — | EP | disclosed |
| EP-0477778-A2 | Benzene, pyridine and pyrimidine derivative | Eisai Co., Ltd. (JP) | 1992-04-01 | — | — | EP | disclosed |