SCHEMBL8921039

SCHEMBL8921039

Cn1cc(C2=C(c3c[nH]c4ccccc34)C(=O)N(C3CCN(CC4CC4)CC3)C2=O)c2ccccc21

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CAMK2D Q13557 11/20 0.61
PRKCG P05129 7/20 0.61
PRKCB P05771 7/20 0.61
PRKCA P17252 7/20 0.61
PRKCH P24723 7/20 0.61
PRKCE Q02156 7/20 0.61
PRKCD Q05655 7/20 0.61
CAMK2B Q13554 6/20 0.61
CAMK2G Q13555 6/20 0.61
CAMK2A Q9UQM7 6/20 0.61
PRKCZ Q05513 5/20 0.61
SRC P12931 3/20 0.61
PIM1 P11309 2/20 0.59
CDK9 P50750 2/20 0.59
CCNT1 O60563 1/20 0.59
PRKACA P17612 8/20 0.56
PRKACB P22694 8/20 0.56
PRKACG P22612 7/20 0.56
CDK2 P24941 4/20 0.56
CCNE2 O96020 3/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8920197 0.88 CCNT1 (0.66) CAMK2DPRKCGPRKCBPRKCAPRKCH
SCHEMBL8920763 0.85 CCNT1 (0.61) CAMK2DPRKCGPRKCBPRKCAPRKCH
SCHEMBL7195523 0.77 CCNT1 (0.81) CAMK2DPRKCGPRKCBPRKCAPRKCH
SCHEMBL6423238 0.76 PRKCG (1.00) CAMK2DPRKCGPRKCBPRKCAPRKCH
SCHEMBL30834685 0.73 CCNT1 (0.74) CAMK2DPRKCGPRKCBPRKCAPRKCH
SCHEMBL9376063 0.73 PRKACA (0.68) CAMK2DPRKCGPRKCBPRKCAPRKCH
SCHEMBL7822250 0.73 CDK4 (1.00) CAMK2DPRKCGPRKCBPRKCAPRKCH
SCHEMBL7831969 0.73 PRKACA (0.77) CAMK2DPRKCGPRKCBPRKCAPRKCH
SCHEMBL8482614 0.71 PIM1 (0.66) CAMK2DPRKCGPRKCBPRKCAPRKCH
SCHEMBL18392163 0.70 CDK4 (0.68) CAMK2DPRKCGPRKCBPRKCAPRKCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5672618-A TREATING DIABETIC COMPLICATIONS ELI LILLY AND COMPANY (US) 1997-09-30 US disclosed