Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 2/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4865849 | 0.85 | CYP2E1 (0.49) | HPGDSCYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL5924494 | 0.85 | PDE10A (0.47) | HPGDSCYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL651699 | 0.85 | CYP2E1 (0.50) | HPGDSCYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL13978068 | 0.84 | HPGDS (0.55) | HPGDSCYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL4944561 | 0.83 | HPGDS (0.49) | HPGDSCYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL8657334 | 0.83 | PDE10A (0.46) | HPGDSCYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL4869521 | 0.83 | PDE10A (0.46) | HPGDSCYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL17874829 | 0.82 | TLR8 (0.52) | HPGDSCYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL8830178 | 0.82 | PDE10A (0.45) | HPGDSCYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL12985709 | 0.81 | PDE10A (0.49) | HPGDSCYP2E1CYP3A4CYP2A6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668136-A | ANTIARTERIOSCLEROTIC AGENT, CHOLESTEROL O-ACYLTRANSFERASE INHIBITOR | EISAI CO., LTD. (JP) | 1997-09-16 | — | — | US | disclosed |
| CN-1122331-A | Benzene, pyridine and pyrimidine derivative | EISAI CO LTD (JP) | 1996-05-15 | — | — | CN | disclosed |
| EP-0477778-B1 | Benzene, pyridine and pyrimidine derivative | EISAI CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0615970-A1 | Benzene, pyridine and pyrimidine derivative | Eisai Co., Ltd. (JP) | 1994-09-21 | — | — | EP | disclosed |
| EP-0477778-A2 | Benzene, pyridine and pyrimidine derivative | Eisai Co., Ltd. (JP) | 1992-04-01 | — | — | EP | disclosed |