Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6421705 | 0.84 | TLR8 (0.39) | NPC1RAB9ATLR8KDM4CKDM5B | |
| SCHEMBL8653720 | 0.84 | QPCT (0.42) | CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL4869521 | 0.84 | PDE10A (0.46) | PDE10AHPGDSCYP2E1CYP3A4CYP2A6 | |
| SCHEMBL4944561 | 0.84 | HPGDS (0.49) | PDE10AHPGDSCYP2E1CYP3A4CYP2A6 | |
| SCHEMBL6423436 | 0.84 | CYP2A6 (0.65) | HPGDSCYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL8921117 | 0.83 | HPGDS (0.51) | PDE10AHPGDSCYP2E1CYP3A4CYP2A6 | |
| SCHEMBL17874829 | 0.83 | TLR8 (0.52) | PDE10AHPGDSCYP2E1CYP3A4CYP2A6 | |
| SCHEMBL8830178 | 0.83 | PDE10A (0.45) | PDE10AHPGDSCYP2E1CYP3A4CYP2A6 | |
| SCHEMBL4865849 | 0.82 | CYP2E1 (0.49) | PDE10AHPGDSCYP2E1CYP3A4CYP2A6 | |
| SCHEMBL5924494 | 0.82 | PDE10A (0.47) | PDE10AHPGDSCYP2E1CYP3A4CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680967-B1 | Erythromycin derivatives, their process of preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (FR) | 1998-10-14 | — | — | EP | claimed |
| EP-0680967-B1 | Erythromycin derivatives, their process of preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (FR) | 1998-10-14 | — | — | EP | disclosed |