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SCHEMBL8921553

SCHEMBL8921553

CC(CCN(CCCCNC(=O)CC(=O)NCCCCCCNC(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)Cc1ccccc1)NC(=O)OC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ APP P05067 2/20 0.39
▸ MAPT P10636 1/20 0.38
▸ MEN1 O00255 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ SIRT5 Q9NXA8 1/20 0.37
▸ SIRT2 Q8IXJ6 1/20 0.37
▸ CTSK P43235 2/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ PTGES O14684 1/20 0.36
▸ AKT1 P31749 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8920849 1.00 APP (0.39) APPMAPTMEN1KMT2ASIRT5
SCHEMBL8920834 1.00 APP (0.39) APPMAPTMEN1KMT2ASIRT5
SCHEMBL8921550 1.00 APP (0.39) APPMAPTMEN1KMT2ASIRT5
SCHEMBL8921535 1.00 APP (0.39) APPMAPTMEN1KMT2ASIRT5
SCHEMBL8921597 0.94 CTSK (0.41) APPMAPTMEN1KMT2ACTSK
SCHEMBL8921748 0.94 CTSK (0.41) APPMAPTMEN1KMT2ACTSK
SCHEMBL8921588 0.94 CTSK (0.41) APPMAPTMEN1KMT2ACTSK
SCHEMBL8921737 0.94 CTSK (0.41) APPMAPTMEN1KMT2ACTSK
SCHEMBL8919650 0.93 CTSK (0.37) APPMAPTMEN1KMT2ASIRT5
SCHEMBL8921657 0.93 MAPT (0.41) APPMAPTMEN1KMT2ASIRT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5637613-A ANTITUMOR AGENT; IMMUNOSUPPRESSANTS FOURNIER INDUSTRIE ET SANTE (FR) 1997-06-10 — — US disclosed