Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 6/20 | 0.58 |
| ▸ | CTSS | P25774 | 8/20 | 0.55 |
| ▸ | CTSK | P43235 | 7/20 | 0.55 |
| ▸ | CTSB | P07858 | 3/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920614 | 1.00 | GHSR (0.58) | GHSRCTSSCTSKCTSBCTSL | |
| SCHEMBL7515055 | 0.91 | CTSS (0.56) | GHSRCTSSCTSKCTSBCTSL | |
| SCHEMBL3696059 | 0.91 | GHSR (0.49) | GHSRCTSSCTSKCTSBCTSL | |
| SCHEMBL3696061 | 0.91 | GHSR (0.49) | GHSRCTSSCTSKCTSBCTSL | |
| SCHEMBL3708374 | 0.85 | CTSS (0.52) | CTSSCTSKCTSBCTSLALDH1A1 | |
| SCHEMBL3708373 | 0.85 | CTSS (0.52) | CTSSCTSKCTSBCTSLALDH1A1 | |
| SCHEMBL8920617 | 0.84 | CTSS (0.48) | GHSRCTSSCTSKCTSBCTSL | |
| SCHEMBL7976216 | 0.83 | GHSR (0.48) | GHSRCTSSCTSKCTSBNAALAD2 | |
| SCHEMBL7976208 | 0.83 | GHSR (0.48) | GHSRCTSSCTSKCTSBNAALAD2 | |
| SCHEMBL14102903 | 0.82 | GHSR (0.60) | GHSRCTSSNAALAD2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660840-B1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996026729-A1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES AS ECE INHIBITORS | CIBA-GEIGY AG (CH) | 1996-09-06 | — | — | WO | disclosed |
| US-5550119-A | ENDOTHELIN-CONVERTING ENZYM INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-08-27 | — | — | US | disclosed |
| US-5273990-A | 5-Phosphonomethyleneamino aryl-substitued alkylene-1H-tetazoles | CIBA-GEIGY CORPORATION (US) | 1993-12-28 | — | — | US | disclosed |