Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | PDE6D | O43924 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8924450 | 0.83 | MAPT (0.42) | MAPT | |
| SCHEMBL8400979 | 0.82 | DDB1 (0.45) | LMNAIDO1ALDH1A1MAPTMEN1 | |
| SCHEMBL8919304 | 0.77 | HTR2A (0.40) | IDO1ALDH1A1TNKS2MEN1KMT2A | |
| SCHEMBL8920778 | 0.77 | MAPT (0.42) | LMNAIDO1ALDH1A1TNKS2CYP19A1 | |
| SCHEMBL8921094 | 0.76 | LMNA (0.52) | LMNAALDH1A1TNKS2CYP19A1MAPT | |
| SCHEMBL8924355 | 0.74 | SLC6A2 (0.47) | LMNAMAPTMEN1KMT2A | |
| SCHEMBL8921450 | 0.74 | LMNA (0.44) | LMNAMAPT | |
| SCHEMBL8402167 | 0.71 | DDB1 (0.47) | ALDH1A1MAPTMEN1KMT2APBRM1 | |
| SCHEMBL8921833 | 0.70 | HTR2A (0.39) | LMNAIDO1ALDH1A1MAPTMEN1 | |
| SCHEMBL28972311 | 0.68 | IDO1 (0.61) | LMNAIDO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |