Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 13/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 13/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8919304 | 0.85 | HTR2A (0.40) | SLC6A2SLC6A3TP53MAPK1MEN1 | |
| SCHEMBL8921450 | 0.85 | LMNA (0.44) | SLC6A3LMNAMAPT | |
| SCHEMBL8400979 | 0.82 | DDB1 (0.45) | MEN1LMNAMAPTKMT2A | |
| SCHEMBL8924450 | 0.80 | MAPT (0.42) | TP53MAPK1MAPT | |
| SCHEMBL8920778 | 0.80 | MAPT (0.42) | NPC1RAB9AMEN1LMNAMAPT | |
| SCHEMBL8922817 | 0.79 | SLC6A2 (0.51) | SLC6A2SLC6A3SLC6A4TP53CYP1A2 | |
| SCHEMBL8923872 | 0.75 | ATM (0.45) | TP53CYP1A2CYP2C19CYP2C9TSHR | |
| SCHEMBL8922047 | 0.74 | LMNA (0.41) | MEN1LMNAMAPTKMT2A | |
| SCHEMBL8399414 | 0.70 | ALDH1A1 (0.44) | SLC6A2SLC6A3SLC6A4TP53RAB9A | |
| SCHEMBL8919347 | 0.70 | MEN1 (0.44) | SLC6A2SLC6A3SLC6A4TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |