Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.40 |
| ▸ | ITGAL | P20701 | 2/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetomilast SCHEMBL29369138 | 0.77 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| Tetomilast SCHEMBL436663 | 0.77 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8923733 | 0.77 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| Hydrochloric Acid SCHEMBL8924979 | 0.76 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL9413051 | 0.76 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL852122 | 0.76 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| Hydrochloric Acid SCHEMBL8924868 | 0.75 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8923420 | 0.75 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8922486 | 0.74 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8924903 | 0.74 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639770-A | SUPEROXIDE INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0600092-A1 | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |