SCHEMBL8922786

SCHEMBL8922786

Cc1cc(C#N)cc(C)c1OCCCc1ccncc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN8A Q9UQD0 2/20 0.42
CYP19A1 P11511 2/20 0.41
CYP11B1 P15538 2/20 0.41
CYP11B2 P19099 2/20 0.41
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
GRM5 P41594 1/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
HRH1 P35367 2/20 0.36
LTA4H P09960 1/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
FNTA P49354 1/20 0.35
FNTB P49356 1/20 0.35
PGGT1B P53609 1/20 0.35
NAAA Q02083 1/20 0.34
TSHR P16473 1/20 0.34
HSD17B10 Q99714 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8923501 0.84 SCN8A (0.49) SCN8ACYP19A1CYP11B1CYP11B2CYP3A4
SCHEMBL8663366 0.78 SCN8A (0.47) SCN8ACYP3A4CYP2D6CYP2C9GRM5
SCHEMBL8992092 0.76 SCN8A (0.39) SCN8AGRM5
SCHEMBL8824433 0.75 SCN8A (0.38) SCN8ACYP19A1CYP11B1CYP11B2CYP3A4
SCHEMBL8824480 0.75 SCN8A (0.38) SCN8ACYP3A4CYP2D6CYP2C9GRM5
SCHEMBL9090767 0.74 SCN8A (0.35) SCN8AMEN1KMT2ALTA4H
SCHEMBL8554425 0.73 SCN8A (0.43) SCN8ACYP3A4CYP2D6CYP2C9GRM5
SCHEMBL8824504 0.73 POLB (0.42) SCN8ACYP3A4CYP2D6CYP2C9MEN1
SCHEMBL6979992 0.73 SCN8A (0.36) SCN8AALDH1A1MAPTTSHR
SCHEMBL8824523 0.73 SCN8A (0.37) SCN8AGRM5MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5618821-A VIRICIDES, PICORNAVIRUS SANOFI, S.A. (FR) 1997-04-08 US disclosed
WO-1995031438-A1 THERAPEUTIC PHENOXYALKYLHETEROCYCLES SANOFI WINTHROP, INC. (US) 1995-11-23 WO disclosed