Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 9/20 | 0.46 |
| ▸ | ECE1 | P42892 | 5/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | MMEL1 | Q495T6 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922872 | 1.00 | MME (0.46) | MMEECE1AGTR2KDM4EALDH1A1 | |
| SCHEMBL8924951 | 0.90 | KDM4E (0.38) | MMEECE1AGTR2KDM4EALDH1A1 | |
| SCHEMBL8924880 | 0.90 | KDM4E (0.38) | MMEECE1AGTR2KDM4EALDH1A1 | |
| SCHEMBL8921693 | 0.89 | ECE1 (0.46) | MMEECE1AGTR2MAPTMMEL1 | |
| SCHEMBL8921715 | 0.89 | ECE1 (0.46) | MMEECE1AGTR2MAPTMMEL1 | |
| SCHEMBL8921873 | 0.89 | ITGA4 (0.38) | MMEECE1AGTR2KDM4EHPGD | |
| SCHEMBL8922274 | 0.88 | MME (0.47) | MMEECE1AGTR2MMEL1 | |
| SCHEMBL8922261 | 0.88 | MME (0.47) | MMEECE1AGTR2MMEL1 | |
| SCHEMBL8923691 | 0.88 | ROCK2 (0.36) | MMEECE1AGTR2 | |
| SCHEMBL8923716 | 0.88 | ROCK2 (0.36) | MMEECE1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660840-B1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | disclosed |
| US-5550119-A | ENDOTHELIN-CONVERTING ENZYM INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-08-27 | — | — | US | disclosed |
| EP-0660840-A1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES. | CIBA GEIGY AG (CH) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994005677-A1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1994-03-17 | — | — | WO | disclosed |
| US-5273990-A | 5-Phosphonomethyleneamino aryl-substitued alkylene-1H-tetazoles | CIBA-GEIGY CORPORATION (US) | 1993-12-28 | — | — | US | disclosed |