SCHEMBL8922942

SCHEMBL8922942

CC1(C)C[Si](C)(CCCCCc2ccc(C(=O)Oc3cc(C#N)ccc3-c3ccccc3)cc2)[Si](C)(C)[Si](C)(C)O1

nearest known ligand 0.35

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.35
CYP11B1 P15538 2/20 0.35
CYP11B2 P19099 2/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.33
FAAH O00519 2/20 0.33
KDM1A O60341 6/20 0.33
BCHE P06276 1/20 0.32
HRH1 P35367 1/20 0.31
MGLL Q99685 1/20 0.31
NAMPT P43490 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8913896 0.86 PTGDR2 (0.36) CYP19A1CYP11B1CYP11B2PTGDR2KDM1A
SCHEMBL8912832 0.80 CYP19A1 (0.45) CYP19A1CYP11B1CYP11B2PTGDR2FAAH
SCHEMBL8912688 0.80 CYP19A1 (0.45) CYP19A1CYP11B1CYP11B2PTGDR2FAAH
SCHEMBL6416735 0.79 RARB (0.49) CYP19A1CYP11B1CYP11B2PTGDR2BCHE
SCHEMBL8913699 0.79 PTGDR2 (0.33) PTGDR2
SCHEMBL6417850 0.78 RARB (0.47) CYP19A1CYP11B1CYP11B2PTGDR2KDM1A
SCHEMBL8922934 0.75 CYP19A1 (0.40) CYP19A1CYP11B1CYP11B2PTGDR2FAAH
SCHEMBL8914877 0.74 PTGDR2 (0.44) CYP19A1CYP11B1CYP11B2PTGDR2FAAH
SCHEMBL8913874 0.73 CYP11B1 (0.43) CYP19A1CYP11B1CYP11B2PTGDR2FAAH
SCHEMBL8912154 0.73 F2 (0.37) MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE35462-E Silylated benzoic acid derivatives CONSORTIUM FUR ELEKOCHEMISCHE IND. GMBH (DE) 1997-02-25 US disclosed
US-5277838-A Silylated benzoic acid derivatives CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1994-01-11 US disclosed
US-5106530-A Liquid crystals Consortium Fur Elektrochemische Ind. (DE) 1992-04-21 US disclosed