SCHEMBL8923050

SCHEMBL8923050

O=C(O)c1ccc(Oc2ccc(-c3cccc(C(F)(F)F)c3)cc2C(F)(F)F)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 1/20 0.51
SERPINE1 P05121 1/20 0.51
RXRA P19793 3/20 0.50
RXRB P28702 3/20 0.50
RXRG P48443 2/20 0.50
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
KDM4E B2RXH2 2/20 0.49
ALDH1A1 P00352 1/20 0.49
SRD5A2 P31213 2/20 0.49
SCN9A Q15858 2/20 0.46
PLG P00747 1/20 0.45
PLAU P00749 1/20 0.45
PLAT P00750 1/20 0.45
IP6K1 Q92551 1/20 0.44
IP6K3 Q96PC2 1/20 0.44
IP6K2 Q9UHH9 1/20 0.44
MAPK14 Q16539 1/20 0.44
LPAR1 Q92633 1/20 0.43
LPAR5 Q9H1C0 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8922262 0.82 MAOB (0.47) MEN1KMT2AALDH1A1SCN9ARAB9A
SCHEMBL2344585 0.81 RXRA (0.72) NR4A2RXRARXRBRXRGMEN1
SCHEMBL29784281 0.81 RXRA (0.72) NR4A2RXRARXRBRXRGMEN1
SCHEMBL8923163 0.79 RXRA (0.47) SERPINE1RXRARXRBRXRGSRD5A2
SCHEMBL31028173 0.78 SCN9A (0.56) KDM4ESCN9A
SCHEMBL693792 0.77 NR4A2 (0.62) NR4A2RXRARXRBRXRGSRD5A2
SCHEMBL8059639 0.77 TTR (0.62) RXRARXRBRXRGSRD5A2SCN9A
SCHEMBL10670283 0.77 RXRA (0.54) NR4A2SERPINE1RXRARXRBRXRG
SCHEMBL9847810 0.76 RARG (0.64) RXRARXRBRXRG
SCHEMBL22319369 0.76 PTGER4 (0.70) MEN1KMT2AMAPK14MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5670084-A Alignment layer material for liquid crystal display devices HOECHST AKTIENGESELLSCHAFT (DE) 1997-09-23 US disclosed
EP-0708149-A1 Alignment layer material for liquid crystal display devices HOECHST AKTIENGESELLSCHAFT (DE) 1996-04-24 EP disclosed