Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 10/20 | 0.47 |
| ▸ | MAOA | P21397 | 9/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7489249 | 0.82 | MAOB (0.56) | HTTMAOBMAOAEPHX2LMNA | |
| SCHEMBL9730163 | 0.77 | HTT (0.56) | HTTMAOBMAOAEPHX2LMNA | |
| SCHEMBL8921236 | 0.77 | LMNA (0.51) | HTTLMNAALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL8786235 | 0.77 | MAOB (0.56) | HTTMAOBMAOAEPHX2LMNA | |
| SCHEMBL3006703 | 0.76 | HTT (0.79) | HTTMAOBMAOAEPHX2LMNA | |
| SCHEMBL9730392 | 0.76 | HTT (0.51) | HTTMAOBMAOAEPHX2LMNA | |
| SCHEMBL8923640 | 0.75 | TSHR (0.35) | EPHX2NPC1MEN1KMT2A | |
| SCHEMBL8786021 | 0.75 | MAOB (0.61) | HTTMAOBMAOAEPHX2LMNA | |
| SCHEMBL5461698 | 0.72 | MAOB (0.54) | HTTMAOBMAOAEPHX2LMNA | |
| SCHEMBL22226781 | 0.71 | LMNA (0.82) | HTTMAOBMAOAEPHX2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684151-A | PROGESTIN AGONISTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0650480-A1 | 1-ARYLSULPHONYL, ARYLCARBONYL AND 1-ARYLPHOSPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994001412-A1 | 1-ARYLSULPHONYL, ARYLCARBONYL AND 1-ARYLPHOSPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-01-20 | — | — | WO | disclosed |