Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | STING1 | Q86WV6 | 4/20 | 0.34 |
| ▸ | TDP2 | O95551 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27528567 | 0.82 | ATM (0.40) | TSHRTDP2HDAC6MEN1KMT2A | |
| SCHEMBL9449446 | 0.77 | PTPN1 (0.40) | TDP2EPHX2 | |
| SCHEMBL27362455 | 0.76 | TDP2 (0.34) | TDP2 | |
| SCHEMBL9449454 | 0.76 | MAPT (0.49) | TDP2MEN1NPC1KMT2A | |
| SCHEMBL8923643 | 0.75 | HTT (0.49) | MEN1NPC1KMT2AEPHX2 | |
| SCHEMBL27357288 | 0.70 | TDP2 (0.30) | TDP2 | |
| SCHEMBL27532024 | 0.69 | PKM (0.43) | TSHRKMT2AEPHX2 | |
| SCHEMBL3693703 | 0.66 | TSHR (0.78) | TSHRMEN1NPC1KMT2A | |
| SCHEMBL4686902 | 0.65 | TSHR (0.55) | TSHRMEN1NPC1KMT2A | |
| SCHEMBL8922539 | 0.64 | TSHR (0.42) | TSHRKMOSTING1MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684151-A | PROGESTIN AGONISTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0650480-A1 | 1-ARYLSULPHONYL, ARYLCARBONYL AND 1-ARYLPHOSPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994001412-A1 | 1-ARYLSULPHONYL, ARYLCARBONYL AND 1-ARYLPHOSPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-01-20 | — | — | WO | disclosed |