Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tert-Butylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.43 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
| ▸ | FABP2 | P12104 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8923974 | 0.81 | PPARG (0.52) | PPARGPPARAMAPTMEN1CYP1A2 | |
| SCHEMBL8923438 | 0.78 | PPARA (0.44) | PPARGPPARAFABP2SLC22A12MAPT | |
| SCHEMBL8924029 | 0.77 | PPARG (0.64) | PPARGPPARAPPARD | |
| SCHEMBL9517990 | 0.76 | CA2 (0.55) | PPARGPPARAFABP2SLC22A12MAPT | |
| Tert-Butylamine SCHEMBL8924062 | 0.76 | PPARA (0.45) | PPARGPPARAPPARD | |
| SCHEMBL8923401 | 0.75 | ADRB3 (0.45) | PPARGPPARAFABP2SLC22A12MAPT | |
| SCHEMBL8923395 | 0.75 | ADRB3 (0.45) | PPARGPPARAFABP2SLC22A12MAPT | |
| Tert-Butylamine SCHEMBL8924413 | 0.75 | PPARA (0.45) | PPARGPPARAMAPTMEN1CYP1A2 | |
| SCHEMBL8922791 | 0.74 | PPARA (0.45) | PPARGPPARAFABP2SLC22A12MAPT | |
| SCHEMBL8923846 | 0.74 | PPARG (0.59) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627205-A | ANTILIPEMIC AGENTS AND ANTIOXIDANTS | ADIR ET COMPAGNIE (FR) | 1997-05-06 | — | — | US | disclosed |