Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 9/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920511 | 0.91 | CCKBR (0.35) | CCKBRRIPK1OPRM1OPRD1 | |
| SCHEMBL9362066 | 0.90 | CCKBR (0.44) | CCKBRALDH1A1MAOBOPRM1OPRD1 | |
| SCHEMBL8922537 | 0.90 | CCKBR (0.44) | CCKBRALDH1A1MAOBOPRM1OPRD1 | |
| SCHEMBL8922202 | 0.90 | CCKBR (0.41) | CCKBRNPC1 | |
| SCHEMBL8920550 | 0.87 | GRIN2B (0.41) | CCKBRALDH1A1LMNA | |
| SCHEMBL8922688 | 0.87 | CCKBR (0.41) | CCKBRRIPK1ALDH1A1NPC1MAOA | |
| SCHEMBL8920125 | 0.85 | HSD11B1 (0.37) | CCKBRALDH1A1TDP1OPRM1OPRD1 | |
| SCHEMBL9365827 | 0.85 | CCKBR (0.36) | CCKBRRIPK1PDE5AMAOAMAOB | |
| SCHEMBL8920539 | 0.85 | CCKBR (0.36) | CCKBRRIPK1PDE5AMAOAMAOB | |
| SCHEMBL9362708 | 0.81 | CCKBR (0.44) | CCKBRRIPK1ALDH1A1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |