SCHEMBL8924429

SCHEMBL8924429

CCCc1c(Cl)ccc(C(=O)O)c1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.44
ALDH1A1 P00352 5/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
TP53 P04637 1/20 0.40
CASP1 P29466 1/20 0.40
CLCN2 P51788 2/20 0.39
AKR1C2 P52895 1/20 0.38
AKR1C1 Q04828 1/20 0.38
LMNA P02545 1/20 0.38
KDM4E B2RXH2 3/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
MCL1 Q07820 1/20 0.37
GABRP O00591 1/20 0.37
GABRD O14764 1/20 0.37
GABRA1 P14867 1/20 0.37
GABRB1 P18505 1/20 0.37
GABRG2 P18507 1/20 0.37
GABRB3 P28472 1/20 0.37
GABRA5 P31644 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9706039 0.87 PPARA (0.50) ALDH1A1AKR1C2AKR1C1MEN1KMT2A
SCHEMBL8923065 0.87 PPARA (0.50) ALDH1A1AKR1C2AKR1C1MEN1KMT2A
SCHEMBL7514918 0.87 PPARA (0.50) ALDH1A1AKR1C2AKR1C1MEN1KMT2A
SCHEMBL10397526 0.85 TSHR (0.47) TSHRALDH1A1SMN1; SMN2TP53CASP1
SCHEMBL18298996 0.84 TSHR (0.46) TSHRALDH1A1SMN1; SMN2TP53CASP1
SCHEMBL8924183 0.80 F7 (0.47) TSHRALDH1A1LMNAKDM4EMCL1
SCHEMBL18298870 0.79 TSHR (0.48) TSHRALDH1A1SMN1; SMN2TP53CASP1
SCHEMBL7644125 0.79 TSHR (0.53) TSHRALDH1A1TP53LMNAKDM4E
SCHEMBL21221620 0.79 MCL1 (0.47) CLCN2AKR1C2AKR1C1MCL1PPARA
SCHEMBL8133689 0.79 TSHR (0.44) TSHRALDH1A1SMN1; SMN2TP53CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5688959-A MULTICOLOR DYE IMAGE AND INFRARED RADIATION ABSORBER WITH 1-HYDROXY-2-N-(5-ALKYLTHIAZOL-2-YL)NAPHTHAMIDE COUPLERS FORMING QUINONE IMINE DYES AGFA-GEVAERT, N.V. (BE) 1997-11-18 US disclosed
US-5030544-A 1-hydroxy-2-n(5-alkyl thiazol 2-yl) naphthamides, form quinone-imine dyes AGFA-GEVAERT, N.V. (BE) 1991-07-09 US disclosed
EP-0176628-B1 PHOTOGRAPHIC COLOUR ELEMENTS AGFA-GEVAERT N.V. (BE) 1987-11-25 EP disclosed
EP-0084692-B1 METHOD OF DISPERSING PHOTOGRAPHIC ADJUVANTS IN A HYDROPHILIC COLLOID COMPOSITION AGFA-GEVAERT N.V. (BE) 1986-06-11 EP disclosed
EP-0176628-A1 Photographic colour elements AGFA-GEVAERT N.V. (BE) 1986-04-09 EP disclosed
US-4430421-A USING IHYDROXYMETHYL(5,2,1,0(2,6))TRICYCLODECANE, OR CARBOXYLIC, PHOSPHORIC, OR PHOSPHONIC DIESTERS THEREOF AGFA-GEVAERT, N.V. (BE) 1984-02-07 US disclosed
US-4430422-A USING 1,3-DIALKYLOXY-2-PROPANOLS AND CARBOXYLIC, PHOSPHORIC OR PHOSPHONIC ESTERS THEREOF AGFA-GEVAERT, N.V. (BE) 1984-02-07 US disclosed
EP-0084694-A1 Method of dispersing photographic adjuvants in hydrophilic colloid compositions AGFA-GEVAERT N.V. (BE) 1983-08-03 EP disclosed
EP-0084692-A2 Method of dispersing photographic adjuvants in a hydrophilic colloid composition AGFA-GEVAERT N.V. (BE) 1983-08-03 EP disclosed
US-4345025-A CYAN DYE, COUPLERS FUJI PHOTO FILM CO., LTD. (JP) 1982-08-17 US disclosed
US-4296199-A CONTAINING A CYAN COLOR FORMING COUPLER FUJI PHOTO FILM CO., LTD. (JP) 1981-10-20 US disclosed