SCHEMBL8924465

SCHEMBL8924465

COP(=O)(OC)C(CC=O)c1ccc2c(c1)c(CC(N)=O)cn2Cc1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PLA2G2A P14555 6/20 0.60
ICMT O60725 14/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8926985 0.89 PLA2G2A (0.60) PLA2G2AICMT
SCHEMBL8924471 0.89 PLA2G2A (0.46) PLA2G2AICMT
SCHEMBL8926140 0.86 PLA2G2A (0.53) PLA2G2AICMT
SCHEMBL8924609 0.82 PLA2G2A (0.61) PLA2G2A
SCHEMBL8926514 0.82 PLA2G2A (0.63) PLA2G2AICMT
SCHEMBL8926716 0.81 PLA2G2A (0.60) PLA2G2A
SCHEMBL8926099 0.81 PLA2G2A (0.58) PLA2G2AICMT
SCHEMBL8926715 0.80 PLA2G2A (0.61) PLA2G2A
SCHEMBL8926168 0.78 PLA2G2A (0.63) PLA2G2A
SCHEMBL8924715 0.76 PLA2G2A (0.53) PLA2G2AICMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5684034-A INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE ELI LILLY AND COMPANY (US) 1997-11-04 US disclosed