Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 1/20 | 0.52 |
| ▸ | CDC25B | P30305 | 1/20 | 0.52 |
| ▸ | CDC25C | P30307 | 1/20 | 0.52 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 2/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 11/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198667 | 0.78 | ALDH1A1 (0.72) | PLAUCYP1A1CYP1A2CYP1B1MEN1 | |
| SCHEMBL8924580 | 0.76 | PDE4A (0.55) | CDC25ACDC25BCDC25CDUSP3CYP1A1 | |
| SCHEMBL19196243 | 0.76 | MEN1 (0.63) | CYP1A1CYP1A2CYP1B1MEN1KMT2A | |
| SCHEMBL10675056 | 0.76 | MAPT (0.50) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6197622 | 0.75 | ALDH1A1 (0.65) | CYP1A1CYP1B1MEN1KMT2AMAPT | |
| SCHEMBL2624591 | 0.75 | MAPT (0.63) | CDC25ACDC25BCDC25CDUSP3MEN1 | |
| SCHEMBL17336865 | 0.72 | ALDH1A1 (0.61) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6198574 | 0.72 | ALDH1A1 (0.76) | PLAUCYP1A1CYP1A2CYP1B1MEN1 | |
| SCHEMBL6200225 | 0.72 | ALDH1A1 (0.65) | PLAUCYP1A1CYP1A2CYP1B1MEN1 | |
| SCHEMBL6197729 | 0.71 | ALDH1A1 (0.67) | PLAUCYP1A1CYP1A2CYP1B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639770-A | SUPEROXIDE INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0600092-A1 | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |