Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mequinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Anthracene SCHEMBL8925919 | 0.84 | ESR2 (0.64) | CYP1A2LTA4HESR2APPCYP2A6 | |
| 1-Hydroxy-4-Ethoxybenzene SCHEMBL10587905 | 0.83 | LTA4H (0.51) | CYP1A2ALDH1A1HPGDHSD17B10LTA4H | |
| Mequinol SCHEMBL10589275 | 0.83 | LTA4H (0.46) | CYP1A2LTA4HESR2APPCYP2A6 | |
| SCHEMBL130783 | 0.80 | CYP1A2 (0.69) | CYP1A2ALDH1A1HPGDHSD17B10CYP2A6 | |
| Mequinol SCHEMBL8923068 | 0.80 | MCL1 (0.58) | CYP1A2LTA4HESR2APPCYP2A6 | |
| SCHEMBL11054996 | 0.80 | CYP1A2 (0.55) | CYP1A2ALDH1A1HPGDHSD17B10ESR2 | |
| SCHEMBL1309620 | 0.78 | CYP1A2 (0.67) | CYP1A2ALDH1A1HPGDHSD17B10CYP2A6 | |
| SCHEMBL5400012 | 0.78 | CYP1A2 (0.67) | CYP1A2ALDH1A1HPGDHSD17B10CYP2A6 | |
| SCHEMBL31498551 | 0.78 | CYP1A2 (0.67) | CYP1A2ALDH1A1HPGDHSD17B10CYP2A6 | |
| SCHEMBL28536961 | 0.78 | CYP1A2 (0.67) | CYP1A2ALDH1A1HPGDHSD17B10CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663032-A | NAPHTHOL DERIVATIVE REDUCING AGENT | CANON KABUSHIKI KAISHA (JP) | 1997-09-02 | — | — | US | disclosed |
| EP-0332455-B1 | Photosensitive material and image forming method | CANON KK (JP) | 1996-06-05 | — | — | EP | disclosed |
| EP-0653680-A2 | Photosensitive composition, photosensitive material and image forming method | CANON KABUSHIKI KAISHA (JP) | 1995-05-17 | — | — | EP | disclosed |
| US-5041369-A | Silver Halide, Silver Salt, Reducing Agent, Metal or Organic Dye | CANON KABUSHIKI KAISHA (JP) | 1991-08-20 | — | — | US | disclosed |
| EP-0332455-A2 | Photosensitive material and image forming method | CANON KABUSHIKI KAISHA (JP) | 1989-09-13 | — | — | EP | disclosed |
| EP-0326424-A2 | Photosensitive composition, photosensitive material, and image forming method | CANON KABUSHIKI KAISHA (JP) | 1989-08-02 | — | — | EP | disclosed |