Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.72 |
| ▸ | TSHR | P16473 | 8/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8772268 | 1.00 | HCAR2 (0.72) | HCAR2TSHRHPGDALDH1A1TP53 | |
| Fumaric Acid SCHEMBL10717462 | 1.00 | HCAR2 (0.72) | HCAR2TSHRHPGDALDH1A1TP53 | |
| Fumaric Acid SCHEMBL10717454 | 1.00 | HCAR2 (0.72) | HCAR2TSHRHPGDALDH1A1TP53 | |
| Maleic Acid SCHEMBL28317871 | 1.00 | HCAR2 (0.72) | HCAR2TSHRHPGDALDH1A1TP53 | |
| Ethyl Fumarate SCHEMBL1067038 | 0.96 | HCAR2 (0.80) | HCAR2TSHRHPGDALDH1A1TP53 | |
| Maleic Acid SCHEMBL11165865 | 0.94 | HCAR2 (0.64) | HCAR2TSHRHPGDALDH1A1TP53 | |
| Acrylic Acid Ethyl Ester SCHEMBL40332 | 0.91 | HCAR2 (0.58) | HCAR2TSHRHPGDALDH1A1TP53 | |
| Acrylic Acid Ethyl Ester SCHEMBL28020506 | 0.91 | HCAR2 (0.58) | HCAR2TSHRHPGDALDH1A1TP53 | |
| Acrylic Acid Ethyl Ester SCHEMBL8587658 | 0.91 | HCAR2 (0.58) | HCAR2TSHRHPGDALDH1A1TP53 | |
| Acrylic Acid Ethyl Ester SCHEMBL28059697 | 0.90 | HCAR2 (0.59) | HCAR2TSHRHPGDALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663032-A | NAPHTHOL DERIVATIVE REDUCING AGENT | CANON KABUSHIKI KAISHA (JP) | 1997-09-02 | — | — | US | disclosed |
| EP-0653680-A2 | Photosensitive composition, photosensitive material and image forming method | CANON KABUSHIKI KAISHA (JP) | 1995-05-17 | — | — | EP | disclosed |
| EP-0326424-A2 | Photosensitive composition, photosensitive material, and image forming method | CANON KABUSHIKI KAISHA (JP) | 1989-08-02 | — | — | EP | disclosed |