Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7884617 | 0.84 | MEN1 (0.41) | TSHRGAAHPGDKMT2AALDH1A1 | |
| SCHEMBL2155087 | 0.74 | ALDH1A1 (0.48) | NPSR1KMT2AALDH1A1MEN1CYP3A4 | |
| SCHEMBL12395361 | 0.73 | LMNA (0.54) | TSHRGAAKMT2AALDH1A1MAPK1 | |
| SCHEMBL2738754 | 0.72 | CA1 (0.48) | TSHRGAANPSR1HPGDKMT2A | |
| SCHEMBL1439330 | 0.70 | CA1 (0.52) | TSHRGAANPSR1HPGDKMT2A | |
| SCHEMBL13058300 | 0.70 | CA1 (0.52) | TSHRGAANPSR1HPGDKMT2A | |
| SCHEMBL1521742 | 0.70 | CA1 (0.52) | TSHRGAANPSR1HPGDKMT2A | |
| SCHEMBL9961218 | 0.69 | TSHR (0.52) | TSHRPPARDGAATDP1KMT2A | |
| SCHEMBL159202 | 0.69 | TSHR (0.52) | TSHRPPARDGAATDP1KMT2A | |
| SCHEMBL1305572 | 0.68 | TSHR (0.46) | TSHRPPARDGAATDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5599810-A | ADMINISTERING IN TREATMENT OF BENIGN PROSTATIC HYPERTROPHY, PERIPHERAL VASCULAR DISEASE AND CONGESTIVE HEART FAILURE | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-04 | — | — | US | disclosed |
| EP-0684949-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-12-06 | — | — | EP | disclosed |
| EP-0684949-A4 | CHEMICAL COMPOUNDS. | SMITHKLINE BEECHAM CORP (US) | 1995-10-13 | — | — | EP | disclosed |
| WO-1994019354-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-09-01 | — | — | WO | disclosed |