Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 11/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 10/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 10/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 10/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 10/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.52 |
| ▸ | CFB | P00751 | 3/20 | 0.47 |
| ▸ | HTR1D | P28221 | 3/20 | 0.45 |
| ▸ | HTR1B | P28222 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7029436 | 0.87 | ADRA2C (0.51) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL6950536 | 0.87 | ADRA2A (0.50) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL6581550 | 0.87 | ADRA2A (0.50) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| Hydrochloric Acid SCHEMBL6967227 | 0.86 | ADRA2A (0.49) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL6580986 | 0.85 | ADRA2A (0.45) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL4639205 | 0.84 | ADRA2A (0.47) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL6579469 | 0.84 | ADRA2A (0.44) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL7029441 | 0.82 | HTR1D (0.49) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL4638692 | 0.79 | ADRA2A (0.44) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| Acetic Acid SCHEMBL16699530 | 0.79 | ADRA2A (0.42) | ADRA2AADRA1AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691370-A | 5-(2-imidazolinylamino)benzimidazole compounds useful as alpha-2-adrenoceptor agonists | THE PROCTER & GAMBLE COMPANY (US) | 1997-11-25 | — | — | US | disclosed |
| EP-0736022-A1 | 5-(2-IMIDAZOLINYLAMINO)BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5541210-A | ANALGESICS, ANTIINFLAMMATORY AGENTS, ANTIHISTAMINES OR COUGH MEDICINE | THE PROCTER & GAMBLE COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| US-5478858-A | Respiratory system disorders, gastrointestinal disorders | THE PROCTER & GAMBLE COMPANY (US) | 1995-12-26 | — | — | US | disclosed |
| WO-1995016685-A1 | 5-(2-IMIDAZOLINYLAMINO)BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1995-06-22 | — | — | WO | disclosed |