Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | PKM | P14618 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 5/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1171430 | 0.74 | MEN1 (0.69) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL11396595 | 0.74 | KDM4E (0.52) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL10061924 | 0.73 | ALDH1A1 (0.56) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL3140425 | 0.72 | ALDH1A1 (0.84) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL11393838 | 0.70 | KDM4E (0.53) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL11403993 | 0.69 | NOTUM (0.56) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL20982597 | 0.69 | ALDH1A1 (0.83) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL18890632 | 0.68 | NPC1 (1.00) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL517706 | 0.68 | MEN1 (0.77) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL15315659 | 0.68 | MEN1 (0.61) | KDM4EALDH1A1NPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4269846-A | BENZOHETEROCYCLIC OXADIAZOLONES AND TRIAZOLONES | USV PHARMACEUTICAL CORPORATION (US) | 1981-05-26 | — | — | US | claimed |
| US-5648355-A | MAST CELL DEGRANULATION-BLOCK AGENTS | KOS PHARMACEUTICAL, INC. (US) | 1997-07-15 | — | — | US | disclosed |
| US-4269846-A | BENZOHETEROCYCLIC OXADIAZOLONES AND TRIAZOLONES | USV PHARMACEUTICAL CORPORATION (US) | 1981-05-26 | — | — | US | disclosed |